DNA Duplex Rupture Force Simulator

This page uses finding by Liu and Yan to simulate the loading rate dependent DNA rupture force. Reference: https://pubs.acs.org/doi/10.1021/jacs.3c10923 (Figure below is from this publication.)
The code embedded here is adopted from their python code at google colab. Simulation result will be shown at the bottom: Please open “Rupture P(F)“ to see simulated rupture force.

If you find these tools useful in your work, we ask that you kindly acknowledge NIH support through the Center on Probes for Molecular Mechanotechnology (RM1GM145394), as well as reference the original research article in manuscripts and presentations.

TGT Lifetime Calculator
Sequence & Geometry
💡 Unzipping geometry → put 1
   Shearing geometry → put total nucleotides n
TGT geometry diagram
Fig. TGT geometry: P₁ (open end), P₂ (transition point), shear-stretch vs unzip-stretch modes.
Force & Temperature
Force Range (pN)
Rupture Force Distribution
Lifetime τ(F)
Rupture ρ(F)