DNA Duplex Rupture Force Simulator

This page uses finding by Liu and Yan to simulate the loading rate dependent DNA rupture force. Reference: https://pubs.acs.org/doi/10.1021/jacs.3c10923 (Figure below is from this publication.)
The code embedded here is adopted from their python code at google colab. Simulation result will be shown at the bottom: Please open “Rupture P(F)“ to see simulated rupture force. The salt concentration are fixed by original report as [Na+] = 150 mM.

Note: the simulation reports the wrong rupture force for that scenario if the force range is insufficient. Please check the three of curve in Rupture P(F) is complete bell shape. If not, please increase the force range.

If you find these tools useful in your work, we ask that you kindly acknowledge NIH support through the Center on Probes for Molecular Mechanotechnology (RM1GM145394), as well as reference the original research article in manuscripts and presentations.